Claudin 18 Mouse Monoclonal Antibody (ABT158) - RA12268

Claudin 18 Mouse Monoclonal Antibody (ABT158)

Size: 50μL, 100μL

Catalogue Numbers: RA12268-50, RA12268-100

Citations, Manuals and MSDS Available upon request.

Background: claudin 18 (CLDN18) Homo sapiens This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.155% sodium azide.

Storage Instructions: -20°C/1 year

Applications: IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human

GeneID (Human): 51208

SWISS: P56856

Source: Mouse

Research Use Only