Product Description

Claudin 18 Mouse Monoclonal Antibody (ABT158)

Sizes: 50μL, 100μL

Catalogue Numbers: RA12268-50, RA12268-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: claudin 18 (CLDN18) Homo sapiens This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],

Reactivity: Human

Host: Mouse

Applications: IHC-p, IF(paraffin section)

Alternate Names: Claudin-18

Clonality: Monoclonal

Dilution: IHC-p 1:100-500, IF 1:100-500

Storage: -20°C/1 year

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.155% sodium azide.

Human Gene ID: 51208

Research Use Only