Product Description

Claudin 19 Polyclonal Antibody

Catalogue Numbers: BS62338-50, BS62338-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q8N6F1

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB:1:500~1:1000

Background: The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-19 is a 224 amino acid multi-pass membrane protein that belongs to the claudin family and is expressed as two isoforms due to alternative splicing events. Defects in the gene encoding claudin-19 are the cause of hypomagnesemia renal with ocular involvement (HOMGO), a renal disease characterized by hypomagnesemia, hypercalciuria and nephrocalcinosis.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Claudin 19 polyclonal antibody detects endogenous levels of Claudin 19 protein.

Extra Notes: Western blot (WB) analysis of Claudin 19 polyclonal antibody at 1:500 dilution
LaneA:L02 whole cell lysate
LaneB:HEK293T whole cell lysate
LaneC:A549 whole cell lysate

Bioworld Molecular Weight: ~ 21 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Claudin-19; CLDN19

Immunogen: Synthetic peptide, corresponding to Human Claudin 19.

Conjugate: Unconjugated

Modification: Unmodified