Claudin-19 rabbit pAb - ES1986

Claudin-19 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1986-50, ES1986-100

Citations, Manuals and MSDS Available upon request.

Background: The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010],

Alternate Name: CLDN19; Claudin-19

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human CLDN19. AA range:81-130

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 23kD

Human Gene ID: 149461

Human SWISS Prot NO: Q8N6F1

Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Research Use Only