Claudin-2 (8H11) Mouse mAb - EM1403

Claudin-2 (8H11) Mouse mAb

Sizes: 50μL, 100μL

Catalogue Numbers: EM1403-50, EM1403-100

Citations, Manuals and MSDS Available upon request.

Background: The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines, including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .

Source: Mouse

Applications: WB, IHC

Dilution: WB 1:1, 000-2, 000   IHC:1; 100-1:200

Reactivity: Human, Rat, Mouse

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Monoclonal

Isotype: IgG1

Concentration: 1mg/mL

Observed Band (KD): 25kDa

Human Gene ID: 9075

Human SWISS Prot NO: P57739

Subcellular Location: Cell junction, tight junction, Cell membrane

Research Use Only