Product Description

Claudin-4 (phospho-Y208) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64164-50, BS64164-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellμlar transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecμle. Claudins, which consist of four transmembrane domains and two extracellμlar loops make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellμlar transport through tight junctions. Claudin-4 is not expressed in rat liver, whereas in pancreas, claudin-4 is localized to junctions of the duct epithelia and junctions of acinar cells. In the rat gut, claudin-4 displays highly restricted expression to colonic surface cells. The human claudin-4 gene maps to chromosome 7q11.23.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein, CLDN4, CPER, CPETR1, WBSCR8

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human CLDN4 around the phosphorylation site of Tyrosine 208.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Claudin-4 (phospho-Y208) polyclonal antibody detects endogenous levels of CLDN4 protein only when phosphorylated at Tyr208.

Molecular Weight: ~ 22 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14493

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only