Product Description

Claudin 7 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66138-50, MB66138-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Claudin superfamily consists of many structurally related proteins in humans . These proteins are important structural and functional components of tight junctions in paracellμlar transport . Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues . Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecμle . Claudins, which consist of four transmembrane domains and two extracellμlar loops make up tight junction strands . Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellμlar transport through tight junctions . mRNA studies indicate that Claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis . The gene encoding human Claudin-7 maps to chromosome 17p13 .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: CEPTRL2, CPETRL2, Claudin-7, CLDN-7

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Claudin 7. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of Claudin 7 protein.

Molecular Weight: ~ 22 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O95471

Product: Mouse IgG2a. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only