Claudin-7 (S204) Polyclonal Antibody-BS3763

Claudin-7 (S204) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3763-50, BS3763-100

Sizes: 50µl, 100µl

Swiss-Prot: O95471

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC

Background: The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. mRNA studies indicate that claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis. The gene encoding human claudin-7 maps to chromosome 17p13.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Claudin-7 (S204) polyclonal antibody detects endogenous levels of Claudin-7 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Claudin-7 (S204) pAb at 1:500 dilution
Lane 1: Beas-2B whole cell lysate (40ug)
Lane 2: HEK293T whole cell lysate (40ug)
Lane 3: PC12 whole cell lysate (40ug)
Lane 4: Hela whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Claudin-7 (S204) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 22 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Claudin 7; Claudin7; CLDN-7; CLDN7; CEPTRL2; CPETRL2

Immunogen: Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-7.

Conjugate: Unconjugated

Modification: Unmodified