Product Description

CLCC1 (D429) Polyclonal Antibody

Catalogue Numbers: BS3283-50, BS3283-100

Sizes: 50µl, 100µl

Alternative Name: Chloride channel CLIC-like protein 1; Mid-1-related chloride channel protein 1; CLCC1; KIAA0761; MCLC

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q96S66

Host: Rabbit

Reactivity: Human

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Chloride channels (CLCs) regulate cellular traffic of chloride ions, a critical component of all living cells. CLCs are involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport. CLCC1 (Chloride channel CLIC-like protein 1), also known as MCLC (Mid-1-related chloride channel) or KIAA0761, is a 551 amino acid multi-pass membrane protein that belongs to the chloride channel MCLC family. CLCC1 is related to the Saccharomyces cerevisiaeprotein Mid-1 and is believed to function as an intracellular chloride channel that is expressed in lung, brain, muscle, liver and testis. Localizing to intracellular compartments such as the Golgi apparatus, the endoplasmic reticulum (ER) and the nuclear envelope, CLCC1 is expressed as four isoforms due to alternative splicing events, namely hMCLC-1, hMCLC-2, hMCLC-3 and hMCLC-4.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CLCC1 (D429) polyclonal antibody detects endogenous levels of CLCC1 protein.

Bioworld Molecular Weight: ~ 62 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CLCC1 (D429) pAb at 1:500 dilution
Lane 1: SGC7901 whole cell lysate(40ug)
Lane 2: HCT116 whole cell lysate(40ug)
Lane 3: H1792 whole cell lysate(20ug)

Immunogen: Synthetic peptide, corresponding to amino acids 396-445 of Human CLCC1.

Conjugate: Unconjugated

Modification: Unmodified