Product Description

Cleaved-ADAM12 (E208) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS9342-50, BS9342-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNF (tumor necrosis factor-α), and modμlation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factorlike domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellμlar signaling. ADAM12 (Meltrin-α) is produced as 2 differentially spliced isoforms, a 718 amino acid secreted form (ADAM12S) and a 881 amino acid membrane-bound form (ADAM12L), and is involved in egg-sperm fusion.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, Meltrin-alpha, ADAM12, MLTN, UNQ346, PRO545

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: Synthetic peptide, corresponding to amino acids 208-259 of Human ADAM12.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cleaved-ADAM12 (E208) polyclonal antibody detects endogenous levels of Cleaved-ADAM12 protein.

Molecular Weight: ~ 77, 99 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O43184

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only