Product Description

Cleaved-C1r LC (I464) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA23456-50, RA23456-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:Selective cleavage of Lys (or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42)., function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system., polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE)., PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains., similarity:Belongs to the peptidase S1 family., similarity:Contains 1 EGF-like domain., similarity:Contains 1 peptidase S1 domain., similarity:Contains 2 CUB domains., similarity:Contains 2 Sushi (CCP/SCR) domains., subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: C1R, Complement C1r subcomponent, Complement component 1 subcomponent r

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight: 27

Protein Molecular Weight (kDa): 27

Storage: -20°C/1 year

Human Gene ID: 715

Human SwissProt Number: P00736

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only