Product Description

Cleaved-Caspase 3 p17 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS80393-50, BS80393-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene resμlts in two transcript variants that encode the same protein.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: CPP32, CPP32B, SCA-1, Active Caspase 3, CASP3, active Caspase-3, Caspase 3, Caspase-3 p12, caspase-3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Caspase 3.

Dilution: WB, 1:500 - 1:1000 IHC, 1:100 - 1:200 IF/ICC, 1:100 - 1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cleaved-Caspase 3 p17 polyclonal antibody detects endogenous levels of Cleaved-Caspase 3 p17 protein.

Molecular Weight: ~ 35, 17 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P42574

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only