Product Description

Cleaved-Caspase 4/5 p20 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BZ16485-50, BZ16485-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing resμlts in transcript variants encoding distinct isoforms.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, ELISA

Alternate Names: TX, Mih1, ICH-2, Mih1/TX, ICEREL-II, ICE(rel)II

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 4/5. AA range:221-270

Dilution: WB: 1/500-1/1000 ELISA: 1/10000

Purification: Affinity Purified

Specificity: IgG

Molecular Weight: Calcμlated MW: 43 kDa, Observed MW: 47, 22 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49662/P51878

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only