Cleaved-Caspase-5 p20 (D121) rabbit pAb - ES1021

Cleaved-Caspase-5 p20 (D121) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1021-50, ES1021-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010],

Alternate Name: CASP5; ICH3; Caspase-5; CASP-5; ICE (rel)-III; Protease ICH-3; Protease TY

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 5. AA range:102-151

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 22kD

Human Gene ID: 838

Human SWISS Prot NO: P51878

Subcellular Location: neuron projection, neuronal cell body, IPAF inflammasome complex, NLRP1 inflammasome complex, NLRP3 inflammasome complex, AIM2 inflammasome complex,

Research Use Only