Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA23466-50, RA23466-100
Citations, Manuals and MSDS Available upon request.
Background: CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Alternative Names: CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2
Applications: WB; IHC-p; IF (paraffin section) ; ELISA
Species Cross-Reactivity: Mouse; Rat
Protein MW (KDa): 28+35
Source: Rabbit
Research Use Only