Cleaved-Caspase-6 p18 (D162) rabbit pAb - ES1003

Cleaved-Caspase-6 p18 (D162) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1003-50, ES1003-100

Citations, Manuals and MSDS Available upon request.

Background: CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.

Alternate Name: CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from mouse Caspase 6. AA range:144-193

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 28+35kD

Research Use Only