Product Description

Cleaved-Endostatin (H1572)  Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS9363-50, BS9363-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Collagen type XV (COL15 gene product) and XVIII (COL18 gene product) form the new subgroup MμlTIPLEXIN, within the diverse family of collagens, which contains 19 distinct types of collagens found in vertebrates. Both Collagen Type XV and Type XVIII are characterized by extensive interruptions in their collagenous sequences. Members of the MμlTIPLEXIN subgroup contain polypeptides with mμltiple triple-helical domains separated and flanked by nontriple-helical regions. Type XV is predominantly expressed in internal organs such as adrenal gland, kidney and pancreas. Type XVIII encodes 2 different α1 chains, which have different signal peptides and variant N-terminal non-collagenous NC1 domains of 495 and 303 amino acids. The long variant NC1-434 Type XVIII mRNAs are prominently expressed in liver, while the variant NC1- 303 mRNAs are predominantly expressed in heart, kidney, placenta, prostate, ovary, skeletal muscle and small intestine. Endostatin is a fragment of the Cterminal domain NC1 of Collagen Type XV and Type XVIII that inhibits angiogenesis and tumor growth. Unlike endostatin-XVIII, endostatin-XV does not bind zinc or heparin, however both endostatins can inhibit chorioallantoic membrane angiogenesis induced by basic FGF or VEGF. Collagen Type XV and XVIII are also widely present in basement membrane zones, suggesting their roles in basement membrane-stromal interactions and in-volvement with angiogenic and pathological processes.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Collagen alpha-1(XVIII) chain, Endostatin, Non-collagenous domain 1, NC1, COL18A1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: Synthetic peptide, corresponding to amino acids 1572-1754 of Human Cleaved-Endostatin.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cleaved-Endostatin (H1572) polyclonal antibody detects endogenous levels of Cleaved-Endostatin protein.

Molecular Weight: ~ 20 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P39060

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only