Cleaved-Factor B Bb (K260) Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA23486-50, RA23486-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: complement factor B (CFB) Homo sapiens This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complemen Reactivity: Human, Mouse Host: Rabbit Applications: WB, ELISA Alternate Names: CFB, BF, BFD, Complement factor B, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. Molecular Weight: 57+85 Protein Molecular Weight (kDa): 57+85 Storage: -20°C/1 year Human Gene ID: 629 Human SwissProt Number: P00751 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only