Product Description

Cleaved-ITI-H1 (D672) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7037-50, BS7037-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The inter-α trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I a IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sμlphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resμlting in pericellμlar matrix stabilization. ITI-H1 contains a potential peptide which coμld stimμlate a broad spectrum of phagocytotic cells. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, they are also associated with malignant transformation of lung tissue. ITI-H1 and ITI-H2 are associated with calcium oxalate stone formation in kidney and urine.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Inter-alpha-trypsin inhibitor heavy chain H1, ITI heavy chain H1, ITI-HC1, Serum-derived hyaluronan-associated protein, SHAP, ITIH1, IGHEP1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: Synthetic peptide, corresponding to amino acids 650-700 of Human ITI-H1.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cleaved-ITI-H1 (D672) polyclonal antibody detects endogenous levels of Cleaved-ITI-H1 (71 kDa) protein.

Molecular Weight: ~ 71, 101 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P19827

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only