Product Description

Cleaved-Notch 4 (V1432) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA23520-50, RA23520-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: notch 4 (NOTCH4) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: NOTCH4, INT3, Neurogenic locus notch homolog protein 4, Notch 4, hNotch4

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Molecular Weight: 59

Protein Molecular Weight (kDa): 59

Storage: -20°C/1 year

Human Gene ID: 4855

Human SwissProt Number: Q99466

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only