Cleaved-Notch 4 (V1432) rabbit pAb - ES6409

Cleaved-Notch 4 (V1432) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6409-50, ES6409-100

Citations, Manuals and MSDS Available upon request.

Background: notch 4 (NOTCH4) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which

Alternate Name: NOTCH4; INT3; Neurogenic locus notch homolog protein 4; Notch 4; hNotch4

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human NOTCH4. AA range:1401-1450

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 59kD

Human Gene ID: 4855

Human SWISS Prot NO: Q99466

Subcellular Location: Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.

Research Use Only