Product Description

Cleaved Notch1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS80388-50, BS80388-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellμlar domain consisting of mμltiple epidermal growth factor-like (EGF) repeats, and an intracellμlar domain consisting of mμltiple different domain types. Notch signaling is an evolutionarily conserved intercellμlar signaling pathway that regμlates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: AOS5, AOVD1, TAN1, hN1, NOTCH1, Activated NOTCH1, notch 1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NOTCH1.

Dilution: WB, 1:500 - 1:1000 IHC, 1:100 - 1:200 IF/ICC, 1:100 - 1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cleaved Notch1 polyclonal antibody detects endogenous levels of Cleaved Notch1 protein.

Molecular Weight: ~ 120 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P46531

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only