Cleaved PARP Monoclonal Antibody (Mix) - BT-MCA0024

Cleaved PARP Monoclonal Antibody (Mix)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0024-20, BT-MCA0024-50, BT-MCA0024-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Research Areas: Epigenetics and nuclear signaling; Metabolism; Cancer; Cell biology

Target Protein: PARP1

Applications: IF, ICC, WB, IHC-p

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Poly (ADP-ribose) polymerase 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P09874; Mouse: P11103; Rat: P27008

Synonyms: PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1

GeneID: Human: 14225591

Research Use Only