Product Description

Cleaved-Tumstatin (P1426) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA23528-50, RA23528-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: collagen type IV alpha 3 chain (COL4A3) Homo sapiens Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal r

Reactivity: Human, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: COL4A3, Collagen alpha-3 (IV) chain, Goodpasture antigen

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight: 27

Protein Molecular Weight (kDa): 27

Storage: -20°C/1 year

Human Gene ID: 1285

Human SwissProt Number: Q01955

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only