CLEC6A Polyclonal Antibody
Catalogue Numbers: BS60545-50, BS60545-100
Sizes: 50µl, 100µl
Alternative Name: C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2; CLEC6A; CLECSF10; DECTIN2
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q6EIG7
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: Together, Dectin-1 and Dectin-2 make up the unique subfamily of dendritic cell-associated C-type lectins. Dectin-2 is expressed on antigen-presenting cells, where it interacts with its putative ligands on T cells. That interaction may deliver co-stimulatory signals in naive T cells. Dectin-2 expression is upregulated during monocyte activation and maturation at inflammatory lesions. Broadband UV-B upregulates Dectin-2 expression in Langerhans cells by activating the Dectin-2 gene promoter, suggesting that this protein plays a crucial role in the mediation of UV-induced immunosuppression. In cattle, Dectin-2 expressed by dendritic cells may also play a role in the recognition of invading antigens in lymph nodes. Dectin-2 functions as a pattern recognition receptor for fungi that activates signaling through FcR© to induce innate immune responses.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CLEC6A polyclonal antibody detects endogenous levels of CLEC6A protein.
Bioworld Molecular Weight: ~ 24 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of CLEC6A polyclonal antibody at 1:500 dilution
Lane 1: MCF-7 whole cell lysate
Lane 2: sp2/0 whole cell lysate
Lane 3: PC12 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human CLEC6A
Conjugate: Unconjugated
Modification: Unmodified