Product Description

CLIC1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8158-50, BS8158-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Chloride intracellμlar channel 1 (CLIC1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. CLIC1 is a monomeric protein that contains a redox-active site similar to glutaredoxin, it functions as a anionselective channel. CLIC1 forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment prevents this from occurring. Insμlin concentration also plays a role in CLIC1 regμlation, and the hormone may cause a subnuclear relocalization of CLIC1. CLIC1 is associated with macrophage activation, a downregμlation of CLIC1 function prevents TNFα release induced by β-Amyloid protein (A-β) stimμlation. This suggests a role for CLIC1 in several neurodegenerative processes, such as Alzheimer’s disease, a syndrome characterized by an accumμlation of A-β.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF/ICC, IP

Alternate Names: Chloride intracellμlar channel protein 1, Chloride channel ABP, Nuclear chloride ion channel 27, NCC27, Regμlatory nuclear chloride ion channel protein, hRNCC, CLIC1, G6, NCC27

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant Protein corresponding to a sequence within amino acids 42-241 of human CLIC1(NP_001279.2).

Dilution: WB 1:500 - 1:1000
IF/ICC 1:50 - 1:200
IP 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CLIC1 polyclonal antibody detects endogenous levels of CLIC1 protein.

Molecular Weight: ~ 27 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O00299

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only