Product Description

CNTF Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Sizes: 50µl, 100µl

Catalogue Numbers: BS7317-50, BS7317-100

Swiss-Prot: P26441

Host: Rabbit

CNTF Polyclonal Antibody-BS7317

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat

Applications: WB, IF/ICC

All Applications: WB: 1:500~1:2000
IF/ICC: 1:50~1:200

Background: The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CNTF polyclonal antibody detects endogenous levels of CNTF protein.

Bioworld Molecular Weight: ~ 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of mouse muscle, using CNTF antibody at 1:1000 dilution., Immunofluorescence analysis of C6 cells using CNTF pAb at dilution of 1:100 (40x lens) .

Alternative Name: CNTF; HCNTF

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 24-74 of human CNTF (NP_000605.1).

Modification: Unmodified

Conjugate: Unconjugated