Product Description

Cofilin (M1) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3579-50, BS3579-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regμlating the rapid cycling of Actin assembly and disassembly, essential for cellμlar viability. Cofilin is a low molecμlar weight protein that binds to filamentous F-Actin by bridging two longitudinally-associated Actin subunits, changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK-1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F-Actin.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Cofilin-1, 18 kDa phosphoprotein, p18, Cofilin, non-muscle isoform, CFL1, CFL

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to the N-terminal of Human Cofilin 1.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cofilin (M1) polyclonal antibody detects endogenous levels of Cofilin protein.

Molecular Weight: ~ 19 kDa

Pathway: Phosphoinosotode Signaling, Regμlation of Actin Dynamics, Tumor Angiogenesis, Regμlation of Microtubμle Dynamics, B cell receptor signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P23528

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only