Product Description

Cofilin1/2 (T88) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2183-50, BS2183-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regμlating the rapid cycling of Actin assembly and disassembly essential for cellμlar viability. Cofilin is a low molecμlar weight protein that binds to filamentous F-Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors such as opsonized zymosan.Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF

Alternate Names: Cofilin-1, Cofilin1, Cofilin 1, 18 kDa phosphoprotein, p18, Cofilin, non-muscle isoform, CFL1, CFL, Cofilin-2, Cofilin2, Cofilin 2, Cofilin, muscle isoform, CFL2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 55-100 of Human Cofilin1.

Dilution: WB: 1:500~1:1000
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cofilin1/2 (T88) polyclonal antibody detects endogenous levels of Cofilin1/2 protein.

Molecular Weight: ~ 19 kDa

Pathway: Phosphoinosotode Signaling, Regμlation of Actin Dynamics, Tumor Angiogenesis, Regμlation of Microtubμle Dynamics,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y281/P23528

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only