Product Description

COL18A1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS6856-50, BS6856-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the mμltiplexins, extracellμlar matrix proteins that contain mμltiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellμlar part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain resμlts in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing resμlts in mμltiple transcript variants.

Category: Primary Antibody

Reactivity: Mouse

Host: Rabbit

Applications: WB

Alternate Names: COL18A1, KNO, KNO1, KS

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human COL18A1(NP_085059.2).

Dilution: WB, 1:500 - 1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Polyclonal Antibodies

Molecular Weight: 240kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P39060

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only