COL25A1 rabbit pAb - ES8542

COL25A1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8542-50, ES8542-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Alternate Name: COL25A1

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Mouse

Immunogen: Synthetic peptide from human protein at AA range: 101-150

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 64kD

Human Gene ID: 84570

Human SWISS Prot NO: Q9BXS0

Subcellular Location: Membrane; Single-pass type II membrane protein. After proteolytic cleavage, CLAC is secreted.

Research Use Only