Product Description

Collagen 4 alpha 2 Polyclonal Antibody

Catalogue Numbers: BS67488-50, BS67488-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P08572

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Collagen 4 alpha 2 protein.

Extra Notes: Western blot analysis of Collagen 4 alpha 2 expression in mouse pancreas (A) whole cell lysates.

Bioworld Molecular Weight: ~ 190 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Collagen alpha-2(IV) chain

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Collagen 4 alpha 2. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified