Product Description

Collagen I mouse Monoclonal Antibody (4H10)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0352-20, BT-MCA0352-50, BT-MCA0352-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Research Areas: Signal transduction; Stem cells; Cancer; Tags and; cell markers

Target Protein: COL1A1

Applications: IF, ICC, IHC-p

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Collagen alpha-1(I) chain

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P02452; Mouse: P11087; Rat: P02454

Synonyms: Collagen alpha-1(I) chain; Alpha-1 type I collagen

GeneID: Human: 1277; 1278

Research Use Only