Collagen I rabbit pAb - ES8487

Collagen I rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8487-50, ES8487-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],

Alternate Name: collagen, type I, alpha 2

Source: Rabbit

Applications: WB IF; ELISA

Dilution: WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from Collagen I . at AA range: 1200-1217

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 135kD

Human Gene ID: 1278

Human SWISS Prot NO: P08123/P02452

Subcellular Location: Secreted, extracellular space, extracellular matrix.

Research Use Only