Product Description

Collagen IV Mouse Monoclonal Antibody (5E10)

Sizes: 50μL, 100μL

Catalogue Numbers: RA10690-50, RA10690-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: collagen type IV alpha 1 chain (COL4A1) Homo sapiens This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: IHC-p, IF(paraffin section)

Alternate Names: Collagen alpha-1(IV) chain [Cleaved into: Arresten]

Clonality: Monoclonal

Dilution: IHC-p 1:50-300

Storage: -20°C/1 year

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Human Gene ID: 1282

Protein Molecular Weight（KDa): 161

Molecular Weight: 161

Research Use Only