Collagen IV mouse Monoclonal Antibody (8E5) - BT-MCA0363

Collagen IV mouse Monoclonal Antibody (8E5)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0363-20, BT-MCA0363-50, BT-MCA0363-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.

Research Areas: Signal transduction; Stem cells; Cancer

Target Protein: COL4A1

Applications: IF, ICC, IHC-p

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Collagen alpha-1(IV) chain

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: p02462; Mouse: P02463

Synonyms: Collagen alpha-1(IV) chain

GeneID: Human: 1282

Research Use Only