Collagen IV rabbit pAb - ES8486

Collagen IV rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8486-50, ES8486-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Alternate Name: collagen, type IV, alpha 1

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from Collagen IV . at AA range: 1428-1443

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 130kD

Human Gene ID: 1282

Human SWISS Prot NO: P02462

Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane.

Research Use Only