Connexin 32 (L115) Polyclonal Antibody-BS3527

Connexin 32 (L115) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3527-50, BS3527-100

Sizes: 50µl, 100µl

Swiss-Prot: P08034

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

Background: Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another. Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is effected. For instance, mutations in connexin 32 result in Charcot-Marie-Tooth disease, a demyelinating disease of the peripheral nervous system.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Connexin-32 (L115) polyclonal antibody detects endogenous levels of Connexin-32 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Connexin 32 (L115) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 32 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Gap junction beta-1 protein; Connexin-32; Cx32; GAP junction 28 kDa liver protein; CX32; GJB1

Immunogen: Synthetic peptide, corresponding to amino acids 81-130 of Human Connexin 32.

Conjugate: Unconjugated

Modification: Unmodified