Product Description

Contactin-2 Polyclonal Antibody

Catalogue Numbers: BS5672-50, BS5672-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q02246

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunogobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Contactin-2 polyclonal antibody detects endogenous levels of Contactin-2 protein.

Extra Notes: Western blot (WB) analysis of CNTN2 pAb at 1:500 dilution
Lane1:The Brain tissue lysate of Mouse(40ug)
Lane2:U-87MG whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 135 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Contactin 2; Contactin2; xonal glycoprotein TAG-1; Axonin-1; Axonin 1; Axonin1; Transient axonal glycoprotein 1; TAX-1; CNTN2; AXT; TAG1; TAX1

Immunogen: Synthetic peptide, corresponding to amino acids 157-202 of Human Contactin-2.

Conjugate: Unconjugated

Modification: Unmodified