COPS5 / JAB1 (K191) Polyclonal Antibody-BS2340

COPS5 / JAB1 (K191) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS2340-50, BS2340-100

Sizes: 50µl, 100µl

Swiss-Prot: Q92905

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Junactivation

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: JAB1 (K191) polyclonal antibody detects endogenous levels of JAB1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of COPS5/JAB1 (K191) pAb at 1:1000 dilution
Lane 1: A549 whole cell lysate (40ug)
Lane 2: MCF-7 whole cell lysate (40ug)
Lane 3: The Lung tissue lysate of Rat (40ug)
Lane 4: CT26 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of COPS5 / JAB1 (K191) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 38 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; Jun activation domain-binding protein; COPS5; CSN5; JAB1

Immunogen: Synthetic peptide, corresponding to amino acids 160-212 of Human COPS5 / JAB1.

Conjugate: Unconjugated

Modification: Unmodified