Product Description

COTL1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP6021-50, AP6021-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: COTL1 (coactosin-like 1), also known as CLP, is a 142 amino acid cytoplasmic and cytoskeletal protein that belongs to the actin-binding proteins ADF family and coactosin subfamily. Widely expressed, COTL1 was first identified in slime mold and is found at highest levels in kidney, placenta, lung and peripheral blood leukocytes, with low levels found in pancreas, liver and brain. COTL1 is one of many proteins that participate in regμlation of Actin’s cytoskeleton through a calcium dependent mechanism, but has not been shown to have a direct effect on Actin depolymerization. COTL1 contains one ADF-H domain and interacts with 5-LO (5-lipoxygenase), an enzyme that plays a role in the biosynthesis of leukotriene and is expressed in mμltiple types of leukocytes.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Coactosin-like protein, COTL1, CLP

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human COTL1.

Dilution: WB:1:500~1:1000
IHC:1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Specificity: COTL1 polyclonal antibody detects endogenous levels of COTL1 protein.

Molecular Weight: ~ 16 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q14019

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only