Product Description

COVID-19 S-hIgG1 Human Monoclonal neutralizing Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66243-50, MB66243-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses. The genome of SARS-CoV-2 is similar to other coronaviruses, and is comprised of four key structural proteins: S, the spike protein, E, the envelope protein, M, the membrane protein, and N, the nucleocapsid protein. Coronavirus spike proteins are class I fusion proteins and harbor an ectodomain, a transmembrane domain, and an intracellμlar tail. The highly glycosylated ectodomain projects from the viral envelope surface and facilitates attachment and fusion with the host cell plasma membrane. The ectodomain can be further subdivided into host receptor-binding domain (RBD) (S1) and membrane-fusion (S2) subunits, which are produced upon proteolysis by host proteases at S1/S2 and S2’ sites. S1 and S2 subunits remain associated after cleavage and assemble into crown-like homotrimers. In humans, both SARS-CoV and SARS-CoV-2 spike proteins utilize the angiotensin-converting enzyme 2 (ACE2) protein as a receptor for cellμlar entry. Spike protein subunits represent a key antigenic feature of coronavirus virions, and therefore represent an important target of vaccines, novel therapeutic antibodies, and small-molecμle inhibitors.

Category: Primary Antibody

Reactivity: COVID-19

Host: Human Cells

Applications: ELISA

Alternate Names: Spike glycoprotein, S glycoprotein, E2, Peplomer protein

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Dilution: ELISA: Use at an assay dependent dilution.

Purification: >95%, cμltured in vitro under conditions free from animal derived components.

Specificity: Recognizes COVID-19 S Protein, COVID-19 S-RBD Protein and block ACE-2 receptor binding.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P0DTC2

Product: 1 mg/ml. Human IgG1. Liquid in 0.01M Phosphate Buffered Saline, pH 7.4.

Research Use Only