COX-2 (2G1) Mouse mAb - EM1339

COX-2 (2G1) Mouse mAb

Sizes: 50μL, 100μL

Catalogue Numbers: EM1339-50, EM1339-100

Citations, Manuals and MSDS Available upon request.

Background: Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described.

Alternate Name: PTGS2 antibody, Prostaglandin H2 synthase 2 antibody, PGHS 2 antibody, Glucocorticoid-regulated inflammatory cyclooxygenase antibody

Source: Mouse

Applications: IHC

Dilution: IHC 1:100-200

Reactivity: Human, Mouse, Rat

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Monoclonal

Isotype: IgG1

Concentration: 1mg/mL

Observed Band (KD): 70kDa

Human Gene ID: 5743

Human SWISS Prot NO: P35354

Subcellular Location: Endoplasmic reticulum,  Membrane,  Microsome

Research Use Only