COX2/Cyclooxygenase 2 Rabbit pAb - EA024

COX2/Cyclooxygenase 2 Rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: EA024-50, EA024-100

Citations, Manuals and MSDS Available upon request.

Background: Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described.

Alternate Name: Cyclooxygenase 2, GRIPGHS, hCox 2, PGG/HS, PGH synthase 2, PGHS 2, PHS 2, PHS II, Prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, PTGS2

Source: Rabbit

Applications: WB, IHC

Dilution: WB 1:1, 000 IHC 1:100

Reactivity: Human

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Polyclonal

Isotype: IgG

Concentration: 1mg/mL

Observed Band (KD): 70kDa

Human Gene ID: 5743

Human SWISS Prot NO: P35354

Research Use Only