Product Description

CPSF3L Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS6946-50, BS6946-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q5TA45

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB IF

All Applications: WB: 1:500~1:2000
IHC: 1:50~1:200

Background: RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The integrator complex is a multi-protein complex that associates with the C-terminal domain of Pol II and is involved in small nuclear RNA (snRNA) transcription and 3’-end processing. This interaction is facilitated by phosphorylation of serine-7 on Pol II. CPSF3L (Cleavage and polyadenylation-specific factor 3-like protein), also known as Integrator complex subunit 11 (INTS11), is a 600 amino acid protein that is a component of the integrator complex and is expressed as three isoforms.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CPSF3L polyclonal antibody detects endogenous levels of CPSF3L protein.

Bioworld Molecular Weight: ~ 68 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of CPSF3L polyclonal antibody

Alternative Name: Integrator complex subunit 11; Int11; Cleavage and polyadenylation-specific factor 3-like protein; CPSF3-like protein; Protein related to CPSF subunits of 68 kDa; RC-68; CPSF3L; INTS11; RC68

Immunogen: Recombinant full length Human CPSF3L.

Conjugate: Unconjugated

Modification: Unmodified