Product Description

CRB2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65770-50, BS65770-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CRB2 is a 1, 285 amino acid protein that contains three laminin G-like domains and 15 EGF-like domains and exists as mμltiple alternatively spliced isoforms that are either secreted or membrane bound. Expressed in kidney and retina, as well as in fetal eye and brain, CRB2 is thought to play a role in the morphogenesis of polarized cells and may be involved in DNA repair. Defects in the gene encoding CRB2 are associated with the pathogenesis of autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), the former of which refers to a group of diseases that lead to the degeneration of retinal photoreceptor cells,μltimately resμlting in a loss of vision. The gene encoding CRB2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Crb2, CRUM2_HUMAN, Crumbs homolog 2 (Drosophila), Crumbs homolog 2, Crumbs-like protein 2, RP11-230L22.2.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human CRB2:701-800/1285

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: CRB2 Polyclonal Antibody detects endogenous levels of CRB2 protein.

Molecular Weight: 100, 131 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q5IJ48

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only