Product Description

CRB2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65770-50, BS65770-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: Q5IJ48

Host: Rabbit

Reactivity: Human, Mouse, Rat,

Applications: WB

All Applications: WB=1:500-2000

Background: CRB2 is a 1,285 amino acid protein that contains three laminin G-like domains and 15 EGF-like domains and exists as multiple alternatively spliced isoforms that are either secreted or membrane bound. Expressed in kidney and retina, as well as in fetal eye and brain, CRB2 is thought to play a role in the morphogenesis of polarized cells and may be involved in DNA repair. Defects in the gene encoding CRB2 are associated with the pathogenesis of autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), the former of which refers to a group of diseases that lead to the degeneration of retinal photoreceptor cells, ultimately resulting in a loss of vision. The gene encoding CRB2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CRB2 Polyclonal Antibody detects endogenous levels of CRB2 protein.

Bioworld Molecular Weight: 100,131 kD

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti- CRB2 at 1/1000 dilution

Alternative Name: Crb2; CRUM2_HUMAN; Crumbs homolog 2 (Drosophila); Crumbs homolog 2; Crumbs-like protein 2; RP11-230L22.2.

Immunogen: KLH conjugated synthetic peptide derived from human CRB2:701-800/1285

Conjugate: Unconjugated

Modification: Unmodified