Product Description

CREB3L3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65675-50, BS65675-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CREB3L3 is a 461 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticμlum (ER) and, in response to ER stress, is cleaved and translocated to the nucleus. Expressed exclusively in liver, CREB3L3 functions as a transcription factor that, during ER stress, is thought to activate genes that are involved in both the unfolded protein response and the acute phase response (APR). Additionally, CREB3L3 is underexpressed in hepatocellμlar carcinoma, suggesting a possible role as a tumor suppressor. CREB3L3 functions as a dimer and contains one leucine zipper domain, a KDEL-like sequence and a bZIP domain, through which it conveys its DNA binding ability. Three isoforms of CREB3L3 exist due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep

Host: Rabbit

Applications: FCM

Alternate Names: cAMP responsive element binding protein 3 like 3, cAMP responsive element-binding protein 3 like protein 3, CREB H, CREB/ATF family transcription factor, CREBH, Cyclic AMP responsive element binding protein 3 like protein 3, cAMP-responsive element-binding protein 3-like protein 3, HYST1481, MGC126553, MGC126557, Transcription factor CREB H, CR3L3_HUMAN.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human CREB-H

Dilution: Flow-Cyt=1ug/Test

Purification: affinity purified by Protein A

Specificity: CREB3L3 Polyclonal Antibody detects endogenous levels of CREB3L3 protein.

Molecular Weight: 49kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q68CJ9

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only