CRF Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA20970-50, RA20970-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: corticotropin releasing hormone (CRH) Homo sapiens This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation a Reactivity: Human, Rat, Mouse Host: Rabbit Applications: IHC-p, IF (paraffin section), ELISA Alternate Names: CRH, Corticoliberin, Corticotropin-releasing factor, CRF, Corticotropin-releasing hormone Clonality: Polyclonal Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. Storage: -20°C/1 year Human Gene ID: 1392 Human SwissProt Number: P06850 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only