Product Description

CRM1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10766-50, MB10766-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O14980

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,IHC-F,IHC-P,ICC/IF

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Background: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CRM1 in 3T3Lysates using CRM1 antibody.

Bioworld Molecular Weight: Calculated MW: 123 kDa; Observed MW: 123 kDa

Specificity: IgG

Alternative Name: XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog

Immunogen: A synthetic peptide of human CRM1

Conjugate: Unconjugated

Modification: Unmodified