CRMP-3 rabbit pAb - ES4508

CRMP-3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4508-50, ES4508-100

Citations, Manuals and MSDS Available upon request.

Background: disease:Antibodies against post-translationally modified DPYSL4, also called anti-CV2 autoantibodies, are present in sera from patients with paraneoplastic neurological diseases (PND). PND are disorders of the nervous system associated with various systemic cancers which are not a direct result of the tumor mass or metastasis, but attributed to remote effects of the cancer., function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily., subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.,

Alternate Name: DPYSL4; CRMP3; ULIP4; Dihydropyrimidinase-related protein 4; DRP-4; Collapsin response mediator protein 3; CRMP-3; UNC33-like phosphoprotein 4; ULIP-4

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human DPYSL4. AA range:91-140

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 62kD

Human Gene ID: 10570

Human SWISS Prot NO: O14531

Subcellular Location: Cytoplasm

Research Use Only