Product Description

CRMP2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90334-50, BS90334-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q16555(Human) O08553(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC IHC

All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-2 is involved in axonal growth and guidance. The human CRMP-2 gene maps to 8p21.2, a chromosomal region that has been previously shown to have a significant linkage to schizophrenia and to several deficit symptoms of schizophrenia.

Purification and Purity: Protein affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: CRMP2 polyclonal antibody detects endogenous levels of CRMP2 protein.

Bioworld Molecular Weight: 62 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CRMP2 on different lysates using anti-CRMP2 antibody at 1/5,000 dilution.
Positive control:
Lane 1: Mouse brain tissue
Lane 2: SH-SY-5Y, ICC staining CRMP2 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: DRP-2, CRMP-2, ULIP-2, DPYSL2, CRMP2, ULIP2, Collapsin response mediator protein 2, Collapsin response mediator protein, Collapsin response mediator protein hCRMP 2, CRAM, CRMP 2, CRMP-2, CRMP2, DHPRP 2, DHPRP2, Dihydropyrimidinase 2, Dihydropyrimidinase like 2, Dihydropyrimidinase like 2 long form, Dihydropyrimidinase related protein 2, Dihydropyrimidinase-related protein 2, DPYL 2, DPYL2, DPYL2, DPYSL 2, Dpysl2, DRP-2, DRP2, Musunc 33, Musunc33, N2A3, TOAD 64, TOAD64, ULIP 2 protein, ULIP-2, Ulip2, Unc-33-like phosphoprotein 2,

Immunogen: Recombinant protein with Human CRMP2 aa 100-300.

Conjugate: Unconjugated

Modification: Unmodified